- The physiologic mechanisms associated with the normal sexual response include vascular, neurogenic, psychogenic, & hormonal factors.
- These physiologic mechanisms are coordinated centrally in the hypothalamus, limbic system, & cerebral cortex.
- Drugs may induce erectile dysfunction by altering any of the physiological mechanisms outlined above, i.e. adrenergic inhibition, adrenergic-receptor blockade, anticholinergic action, as well as endocrine & sedative effects.
Central nervous system drugs:
- Benzodiazepines
- Butyrophenones
- Cyclobenzaprine
- Monoamine oxidase inhibitors
- Orphenadrine
- Phenothiazines
- SSRIs
- Thioxanthenes
- Tricyclic antidepressants
- Beta-blockers (esp propranolol)
- Clonidine
- Diuretics
- Guanethidine
- Methyldopa
- Thiazide diuretics
- Antiandrogens
- Antineoplastic drugs
- Cimetidine
- Clofibrate
- Digoxin
- Ethanol
- Finasteride
- Metoclopramide
- Nicotine
- Oestrogens
- Propantheline
- Sedating antihistamines
Tags: Drug-induced - Erectile Dysfunction - Impotence - Male Erectile Dysfunction
Posted by Medicalchemy
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Posted by Medicalchemy
Medicalchemy Group: History of Medicine - Images - Mnemonics - Syndromes - Acute Medicine - Anaesthesiology - Anatomy - Anthropology - Biochemistry - Cardiology - Dentistry - Dermatology - Drug ADR - Drugs - Embryology - Emergency Medicine - Endocrinology - Epidemiology - Family Medicine - Forensic Medicine - Gastroenterology - Genes - Genetics - Geriatrics - Gynecology - Haematology - Health Informatics - Hepatology - Immunology - Infection - Intensive Care - Medical Dictionary - Medical Education - Medical Statistics - Metabolic Medicine - Microbiology - Nephrology - Neuroanatomy - Neuroscience - Nuclear Medicine - Nutrition - Obstetrics - Occupational Health - Oncology - Ophthalmology - Orthopaedics - Otolaryngology - Paediatrics - Palliative Care - Parasitology - Pathology - Pharmacology - Physiology - Proteomics - Psychiatry - Public Health - Radiology - Respiratory - Rehabilitation - Rheumatology - Sports Medicine - Surgery - Toxicology - Tropical Medicine - Urology - Vascular - Virology.
